AstraZeneca Postdoctoral Fellow, Multiple Myeloma Immuno-Oncology (Oncology Bioscience), Cambridge, Massachusetts, USA

This AstraZeneca postdoctoral fellow opening at Oncology Bioscience in Cambridge, Massachusetts, focuses on multiple myeloma immuno-oncology. Candidates must be within four years of receiving their doctoral degree.

Job Details

Job Title: Postdoctoral Fellow, Multiple Myeloma Immuno-Oncology (Oncology Bioscience) 2026

Company: AstraZeneca Oncology Bioscience

Location: Cambridge, Massachusetts, USA

Experience: Postdoc

Reporting Structure: This postdoc role will report to Kayleigh Gallagher (Associate Principal Scientist) and be supported by Omid Tavana (Senior Director) at AstraZeneca.

AstraZeneca Postdoc Job Description

AstraZeneca is seeking a highly motivated and scientifically rigorous postdoctoral fellow to join the Oncology Bioscience group in Cambridge. This position sits at the intersection of cancer biology and innate immunology, centered on a mechanistically novel discovery: that inhibition of a first-in-class kinase target can regulate tumor growth both through direct cell autonomous oncogenic signaling and non-cancer cell autonomous modulation of the innate immune system.

This work is built around a potent and selective first-in-class AstraZeneca compound, grounded in compelling preliminary in vivo data demonstrating that target inhibition drives tumor regression through innate immune engagement in multiple myeloma models. The postdoc will characterize this mechanism, identify the specific innate immune cell types responsible, and evaluate rational combination strategies with T-cell directed therapies.

This AstraZeneca postdoctoral fellow position is a rare opportunity to lead a mechanistically novel program with direct translational relevance, publish in high-impact journals, and work alongside experts in oncology.

Key Responsibilities

  • Lead in vivo studies in syngeneic and xenograft mouse models to establish and characterize the non-cancer cell autonomous function of a first-in-class kinase inhibitor in multiple myeloma.
  • Dissect the mechanistic contribution of individual innate immune cell types through CRISPR-based models, immune cell depletion, and reconstitution experiments.
  • Apply advanced immunophenotyping and transcriptomic platforms, including CyTOF, single-cell RNA-seq, and CITE-seq, to define pathway modulation across innate immune compartments.
  • Evaluate rational combination strategies with T-cell engagers and CAR-T therapies in relevant preclinical models.
  • Drive a clear publication plan, including a first-author review in Year 1 and a first-author research manuscripts over the three-year term.

AstraZeneca Postdoc Eligibility Criteria

  • To qualify as an AstraZeneca postdoctoral fellow, candidates must be within four years of receiving their doctoral degree (PhD, DVM or MD), with the PhD already awarded.
  • Experience: Postdoc

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