Biochemistry Internship at Calico USA
Are you looking for a high-impact biochemistry internship that combines structural biology, protein science, and real-world research? This Intern, Protein Biochemistry – Structural Biology opportunity at Calico offers one of the most competitive Internships for Life Science Graduates, providing hands-on experience in protein characterization within an innovative aging research environment in the Internship in USA.
About the Company
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company focused on advancing the science of aging. Through calico careers, the company integrates advanced technologies, innovative research, and industry partnerships to enable medical breakthroughs and develop interventions that help people live longer, healthier lives.
Internship Details
- Intern Title: Protein Biochemistry – Structural Biology (BS) Intern
- Company: Calico (Calico Life Sciences LLC)
- Location: South San Francisco, CA
- Program Type: Summer Internship (Paid, In-Person)
- Duration: 11–12 weeks (Summer; June–August)
- Format: In-person, South San Francisco
- Mentorship: Matched with at least one Calico scientist
- Compensation: $45–$70 per hour
- Additional Support: Monthly living expenses stipend
- Application Deadline: February 1, 2026.
Biochemistry Internship Position Overview
Calico is seeking a highly motivated Protein Biochemistry Intern to join the Protein Science group. This role involves hands-on work in the structural and functional characterization of proteins, providing exposure to scientific discovery in an industry setting. The intern will collaborate closely with Protein Science team members and cross-functional groups to generate mechanistic insights into proteins of interest.
Program Features:
- Weekly supplemental programming (guest speakers, leadership spotlights, aging science discussions)
- End-of-summer project showcase and poster session
Key Responsibilities
- Express and purify recombinant proteins
- Contribute to structural determination and evaluation of:
- Protein–protein interactions
- Protein–ligand interactions
- Perform and optimize protein activity and/or binding assays
- Communicate scientific results in group meetings and team settings
Required Qualifications for Biochemistry Internship
- Currently pursuing a BS degree in Biology, Biochemistry, Biological Sciences, or a related field
- Experience with recombinant protein work, including:
- Expression in E. coli and/or mammalian systems
- Multi-step protein purification
- Protein analysis and structural characterization
- Knowledge of molecular biology and protein biochemistry principles
- Strong interest in protein biochemistry
- Detail-oriented, organized, and self-motivated
- Strong teamwork and communication skills
- Flexible and able to manage shifting priorities and multiple tasks
Nice-to-Have Skills
- Familiarity with experimental structural biology techniques
- Experience with protein binding or functional assays
- Experience using:
- Electronic lab notebooks (e.g., Benchling)
- Online databases (UniProt, NCBI, Protein Data Bank)
- DNA plasmid design software (SnapGene)
- Protein structure analysis tools (PyMOL, ChimeraX)
Eligibility Requirements for Biochemistry Internship
- Able to work in-person in South San Francisco
- Available for a consecutive 11–12 week period during Summer 2026
- Not graduating before December 2026
- Exception: Students enrolling in a graduate program in Fall 2026
- Must be enrolled in a U.S. university
