We’re looking for those individuals—the creative thinkers and innovation seekers—who are content with nothing short of changing the world. Discover the endless opportunities within the Medical College of Wisconsin (MCW) and be inspired by the work we can do together to improve health, and make a positive, daily impact in our communities. In the role of Postdoctoral Fellow you will be working in Biochemistry .
Purpose
The Volkman laboratory conducts NIH grant-supported research in several areas of chemokine biology, with an emphasis on the structural details of chemokine proteins, their interactions with cell surface receptors, and novel approaches to modify their functions in vivo with small molecule or engineered protein ligands. Actively funded projects with multiple years of future grant support focus on 1) the structural basis of chemokine function, with the goal of developing a comprehensive structure-function atlas of the chemokine network of the human immune system; 2) fragment-based development of small molecule inhibitors of CCL28, a chemokine implicated in pancreatitis and pancreatic cancer; and 3) the thermodynamic origins of metamorphic folding in the human chemokine XCL1. Additional project details can be found in the NIH Reporter database.
According to the National Institute of Health (NIH) and the National Science Foundation (NSF), a postdoc is an individual who has received a doctoral degree (or equivalent) and is engaged in a temporary and defined period of mentored advanced research training to enhance the professional skills and research independence needed to pursue his or her chosen career path. In addition, according to the National Postdoc Association (NPA), Postdoctoral appointees can pursue basic, clinical or translational projects so long as their primary effort is devoted toward their own scholarship. Postdocs are essential to the scholarly mission of the mentor and host institution, and thus are expected to have the freedom to publish the results of their scholarship.
Recent PhD graduates or those anticipating the completion of the PhD degree in the next 12 months in a scientific discipline related to structural biology, computational biology, molecular biophysics, or GPRC pharmacology with an interest in any of the aforementioned projects are encouraged to apply.
Characteristics of a postdoctoral appointment:
It is expected that postdocs at MCW, with the assistance of their supervisor, will:
- Transition to career independence through the development of professional skills that enable the postdoc to actively pursue a career of his/her own choosing.
Be supervised by at least one senior scholar who actively promotes the postdoc’s professional development. - Establish an individual development plan (IDP) that incorporates equally the postdoc’s career and training goals and the mentor’s research goals.
- Pursue basic, clinical, or translational projects so long as effort is focused primarily on research.
- Publish results of the postdoc’s research and scholarship during their appointment.
- The postdoctoral appointment is temporary by nature, the aggregate amount of time spent as a postdoc is recommended to not exceed five years (not including family medical leave or maternity/paternity leave).
- As postdocs are important members of the host institution’s community, appropriate levels of compensation, health care, and other benefits commensurate with their essential status should be afforded, independent of the postdoc’s source of funding.
Primary Functions
- Perform and assist other research personnel with structure-function studies of chemokine-GPCR complexes using NMR spectroscopy, X-ray crystallography, cryoelectron microscopy and other biophysical and biochemical methods.
- Perform and assist other research personnel with measurements of GPCR signaling to assess the presence of and structural origins of biased agonism in the chemokine family.
- Perform and assist other research personnel with high-throughput computational modeling of chemokine-GPCR complexes.
- Perform and assist other research personnel with fragment-based drug discovery targeting the chemokine network.
- Perform and assist other research personnel with computational design and experimental characterization of novel metamorphic or fold-switching proteins.
- Disseminate research results by depositing structures and data in the protein data bank or other public repositories.
- Prepare research results for publication in peer-reviewed journals as primary author or co-author.
- Plan, design and execute complex research studies, procedures and protocols.
Participate in discovery projects. - Coordinate research study activities; lead and manage projects.
- Oversee organization, synthesis and analysis of data and findings.
- Prepare scientific reports, outcome findings and scientific manuscripts.
- Participate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data, develop methodologies, and design and evaluate lab procedures.
- Maintain supplies, may require negotiation with vendors, and track purchase orders.
May oversee the work of laboratory personnel including training and development as well as daily work direction, delegation and establishing priorities.
Knowledge – Skills – Abilities
Required knowledge: biology, chemistry, protein structure, GPCR pharmacology, computer programming, mathematics, bioinformatics, statistics, documentation, records management, data utilization, complex problem solving, critical thinking, resource management, and writing skills
Skills and abilities: This will vary based on the hiring manager’s preferences and should include things that can be learned or trained for.
Preferred Schedule:
M-F 8-5 pm
Medical College Medical College of Wisconsin
