Novartis Next Gen Research Scientist Vacancy – Apply Online
NBC builds the biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy-based therapeutics.
The Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and rAAV. Through cell and viral engineering as well as innovative and rational protein design, the BEGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations
Job Id: 362050BR
Job Title: Research Scientist II, Next Gen AAV Biodistribution
Minimum requirements
What You’ll Bring To The Role:
• BS Degree in pharmaceutical sciences, biochemistry, molecular or cell biology with 3 years of relevant experience. A combination of education and specialized experience may be considered to meet the required number of years of experience for the level of this role.
• Experience with molecular and cellular biology techniques (i.e. ddPCR, ELISA, IHC, NGS, nucleic acid extraction, qPCR, transcriptomics)
• Experience in AAV biology, animal models, gene therapy, molecular virology or AAV engineering are highly desired.
• Willingness to independently pursue assay and technological development of molecular and cellular biology techniques to advance gene therapy
• The position requires the ability to work collaboratively across a dynamic and collaborative scientific and development environment. Therefore, adaptability to emerging project/group needs, excellent communication and presentation skills, both written and verbal, and strong interpersonal skills are required.
• Ability to meet timelines and deliverables in a team-centric environment
Job Description
Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. You will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.
- NBC builds the biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy-based therapeutics.
- The Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and rAAV. Through cell and viral engineering as well as innovative and rational protein design, the BEGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations.
What You’ll Be Doing:
• Lead in vivo biodistribution analysis projects as a team representative to internal gene therapy programs
• Execute assays to analyze in vitro and in vivo samples for AAV characterization and stability with techniques such as PCR/qPCR/ddPCR, IHC/IF, and/or ELISA/MSD.
• Develop molecular biology assays for the specific needs of gene therapy programs.
• Research, develop and onboard new and emerging techniques and technologies for in vivo gene therapy analysis. Use current and new technologies to contribute to AAV platform development.
• Prepare quality data sets and reports adhering to the good research practices and quality culture across NIBR. Present results at appropriate internal and external meetings and conferences.
• Other related duties as assigned.
Novartis Next Gen Research
