Postdoctoral Position in Autophagy, Stress and Development at CNRS I2BC, Paris-Saclay, France

The CNRS Institute for Integrative Biology of the Cell (I2BC, UMR9198) at Paris-Saclay University invites applications for an I2BC postdoctoral position in the Autophagy, Stress and Development team. The role is based in Gif-sur-Yvette, and the application deadline is 26 November 2026, 23:59.

I2BC Postdoctoral Position Job Details

Organization: The CNRS Institute for Integrative Biology of the Cell (I2BC, UMR9198), Paris-Saclay University

Team: Autophagy, Stress and Development (Department of Cell Biology)

Supervisor: Dr. Renaud Legouis

Offer Reference: UMR9198-CHROUL1-165

Position: Postdoctoral

Contract: Researcher on fixed-term contract, full time, 12 months

Start Date: 01/01/2027

Workplace: 91198 Gif-sur-Yvette

Application Deadline: 26 November 2026, 23:59

Project Details

Project: Characterization of the inter-individual variability in stress response and its effects on resilience

Living beings are constantly subjected to environmental variations, such as temperature, which can induce stress and lead to physiological dysfunction. Implementing preventive and curative strategies requires better knowledge of how stress adaptation systems are regulated, and diagnostic strategies that integrate individuals’ adaptive response levels and resilience capacities.

Advances in imaging, sequencing and data analysis allow stress responses and their effects on adaptation to be studied in animal models such as the nematode C. elegans. The team recently developed an acute, non-lethal heat stress in C. elegans to characterise the adaptive response at the individual level; this stress produces two populations of worms with distinct growth, fertility and longevity characteristics.

The project, offered as an I2BC postdoctoral position, aims to identify the gene regulatory network and characterise the mechanisms underlying individual variability in stress adaptation, and the subsequent effects on fitness and health. Mainly based on transcriptomic analyses in C. elegans, including single-nucleus RNA-Seq, the project combines experimental work with C. elegans and bioinformatic analyses, with access to the I2BC sequencing and bioinformatics facilities.

Key Responsibilities

  • Conduct thermal stress experiments on C. elegans strains (controls, mutants and strains expressing fluorescent markers).
  • Perform all transcriptomic analyses (RT-qPCR, RNA-Seq, snRNA-Seq) from sample preparation to bioinformatic data analysis.
  • Draft progress reports for the project coordinator and present data at team and consortium meetings.
  • Monitor the relevant scientific literature and contribute to publications.
  • Mentor Master’s students (opportunities are available).

Eligibility Criteria

Doctorate (PhD) required.

Required Skills

  • Solid experience in global transcriptomic analysis and in using specialised computational tools.
  • Experience with the C. elegans model is a significant asset.
  • A high degree of independence and the ability to collaborate with partners within the team, across technological platforms and with external collaborators.
  • Fluency in English is required.

Salary

Monthly gross salary between €3,131 and €4,341 depending on experience.

Documents Required

  • CV
  • Motivation letter
  • Letters of recommendation

How to Apply for the I2BC Postdoctoral Position

Candidates for the I2BC postdoctoral position must submit a CV, a motivation letter and letters of recommendation via the CNRS portal.

Additional Information

The position is fully funded by the ANR InVariStress project, bringing together two university laboratories and a company’s Research and Innovation department.

Benefits: 44 days annual leave and RTT; 75% public transport reimbursement.

About CNRS I2BC

The I2BC comprises 48 research teams covering integrative biology (biophysics, biochemistry, structural biology, genomics, cell biology, microbiology, virology and bioinformatics).

CLICK HERE FOR THE ORIGINAL NOTIFICATION / APPLY ONLINE

Applications close on 26 November 2026, 23:59, and must be submitted via the CNRS portal.