AstraZeneca Scientist, Bioscience – CVRM Mechanism-of-Action Proteomics Vacancy | Apply Now
An AstraZeneca Proteomics Scientist (Research Scientist) contract opportunity is available in Cambridge, Massachusetts. This role focuses on the mechanisms of action of therapeutic agents in the cardiovascular, renal, and metabolism (CVRM) area, offering an exciting opportunity for qualified candidates to contribute to significant scientific advancements.
- Position: Proteomics Scientist
- Location: Cambridge, Massachusetts, USA
- Job Reference: ASTE000609
- Contract Duration: 12-month fixed-term contract
About AstraZeneca
AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines. Operating in various therapeutic areas, including cardiovascular, renal, and metabolism, AstraZeneca is committed to delivering innovative solutions to improve patient outcomes. The company is headquartered in Cambridge, Massachusetts, and is recognized for its dedication to scientific excellence and patient care.
Job Description: Proteomics Scientist Role
The AstraZeneca Proteomics Scientist (Research Scientist) will join its Chemical Biology and Proteomics group within Discovery Sciences. The successful candidate will design and execute discovery proteomic assays using mass spectrometry for mechanistic studies and target discovery. Responsibilities also include conducting proximity biotinylation studies in cells with automated affinity purification and DIA mass spectrometry, as well as data analysis utilizing bioinformatic pipelines.
Key Responsibilities
- Design and execute discovery proteomic assays using mass spectrometry.
- Conduct proximity biotinylation studies in cells with automated affinity purification and DIA mass spectrometry.
- Perform data analysis with bioinformatic pipelines.
- Maintain electronic lab notebooks.
- Represent the team with project discipline leads and help generate mechanistic hypotheses.
Proteomics Scientist Eligibility Criteria
- Ph.D. in Proteomics, Chemical Biology, Biological Sciences, Biochemistry, or related discipline with at least two years of hands-on proteomics experience (doctoral or postdoctoral research counts).
- Master’s degree with 3–5 years of hands-on proteomics experience.
- Experience in proteomic sample preparation and mammalian cell culture.
- Familiarity with cell-based and proteomic assays for small-molecule mechanism of action.
Required Skills
- Proximity ligation assays.
- LC-MS/MS and semi-automated instrumentation.
- Experience with Spectronaut, Proteome Discoverer, MaxQuant, Skyline, and Xcalibur.
Pay: $49.29 per hour
Why Join AstraZeneca?
AstraZeneca is at the forefront of scientific innovation and is dedicated to improving patient outcomes through its research and development efforts. By joining AstraZeneca, candidates will be part of a collaborative environment that fosters growth, learning, and the pursuit of excellence in science.
The AstraZeneca Proteomics Scientist position presents an excellent opportunity for qualified candidates to engage in impactful scientific research. Interested individuals are encouraged to apply at the earliest to be considered for this vital role in advancing therapeutic solutions.
