Senior Scientist, Protein Characterization at Johnson & Johnson- Apply now!
Johnson & Johnson is committed to innovation in healthcare to prevent, treat, and cure complex diseases. Through expertise in Innovative Medicine and MedTech, we strive to impact health for humanity. Learn more at www.jnj.com.
- Job Function: Discovery & Pre-Clinical/Clinical Development
- Job Sub Function: Biotherapeutics R&D
- Job Category: Senior Scientist, Biotherapeutics R&D (ST6)
- Location: Malvern / United States of America
- Requisition number: R-000542
Job Description:
About Innovative Medicine Our expertise in Innovative Medicine is informed by patients, driving our advancements to develop life-saving medicines. Join us on the journey from lab to life, making a difference for patients. Learn more at www.jnj.com/innovative-medicine. We are looking for a Senior Scientist, Protein Characterization (Forced Degradation Studies) in Malvern, PA to join our team.
Purpose: The Senior Scientist will drive comparability studies related to biologics and perform mass spectrometry assays for product characterization and process development.
Responsibilities:
- Perform protein forced degradation studies
- Characterize degradation pathways and identify PTM CQAs
- Conduct serum stability studies for ADC products
- Write analytical sections for regulatory submissions
- Design and execute LC/MS assays for product characterization
- Maintain lab notebooks and prepare reports in a GMP-compliant manner
Qualifications / Requirements: Required:
- Bachelor’s Degree or Master’s Degree in Analytical Chemistry, Biochemistry, Biotechnology, Protein Formulations, Chemical Engineering, or a related field with 4-6 years of experience is required;
- OR a PhD in Analytical Chemistry, Biochemistry, Biotechnology, Protein Formulations, Chemical Engineering, or a related field with a minimum of 0-2 years of experience following the completion is highly preferred.
- Strong knowledge of protein chemistry and characterization experience with protein characterization using mass spectrometry and liquid chromatography
- Hands-on experience with Mass Spectrometry
- Experience working in a GLP/GMP environment
- Experience performing and managing complex studies
- Ability to balance and contribute to multiple project priorities
- Ability to independently work across other functions (regulatory, QC, process development) to drive studies
- Good written and verbal communication skills
Preferred:
- Experience in forced degradation studies, ADCs, and serum stability studies
- Knowledge of LC/MS peptide mapping methods and CMC processes
Johnson & Johnson is an Equal Opportunity Employer. Candidates with disabilities and protected veterans are encouraged to apply.
Keywords: Senior Scientist, Protein Characterization, Forced Degradation Studies, Protein Chemistry, Mass Spectrometry, Biotherapeutics R&D, Johnson & Johnson
