Black Diamond Therapeutics Intern – Genomic Science
Black Diamond Therapeutics Intern – Genomic Science. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry.
Genomic Science Intern
Req ID: 2021-1101
Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumour-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company’s proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.
We are looking for a Summer Intern to join our Research team. This is a Full-time paid Internship for 3-4 months which can be remote.
The Genomic Science Intern will join our MAP platform team to assemble and curate genomic variant data for disease indications outside oncology.
The intern will work under the supervision of BDTX scientists to assemble and curate variant annotation to enable a computational analysis of potential targets for proof of concept validation beyond oncology.
- Assemble a roster of genes implicated in specific areas of biology associated with significant disease
- Assemble a catalogue of genomic variants associated with this roster of genes from available sources
- Complete manual curation of genomic variants for a subset of prioritized genes, utilizing peer-reviewed literature and selected databases, assigning specific variants to biochemical and clinical annotation categories
- Perform literature analysis to identify genetic variation associated with selected diseases
- Assist MAP computational team in preparing genes of interest for MAP platform evaluation and analysis of results
- Working with the team, prioritize high-value targets for proof of concept validation
- Undergraduate or Graduate students in molecular biology, genetics, biochemistry, or bioinformatics
- Experience in literature and database searching preferred
- Background in cell biological pathway analysis helpful
- Background in the analysis of genetic data helpful.
This job operates in a professional office environment. This role routinely uses standard office equipment.
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
While performing the duties of this job, the employee is occasionally required to stand; walk; sit; use hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb stairs; talk or hear. The employee must occasionally lift or move office products and supplies up to 20 lbs.