PhD Fellowship in Neuroendocrine Prostate Cancer at Cambridge
The Cancer Research UK Cambridge Institute invites applications for a fully funded PhD studentship to study the role of transcription factors and associated proteins in neuroendocrine prostate cancer (NEPC). This exciting opportunity allows students to gain hands-on experience in genomics, proteomics, and molecular biology while working under the guidance of Professor Jason Carroll. The position is ideal for graduates interested in cutting-edge cancer research and advanced biology jobs in oncology.
Job Details
- Job Position: PhD Studentship โ Understanding the Role of Transcription Factors and Associated Proteins in Neuroendocrine Prostate Cancer
- Location: Li Ka Shing Centre, Robinson Way, Cambridge, UK
- Job Type: Full-time, four-year studentship
- Job ID: 52810
- Reference: SW47278
About the Institute
The Cancer Research UK Cambridge Institute (CRUK CI) is a world-leading research center dedicated to understanding cancer biology and translating discoveries into innovative therapies. With a focus on advanced genomics, proteomics, and molecular approaches, CRUK CI provides a collaborative and interdisciplinary environment for training the next generation of cancer scientists.
Job Description
This PhD fellowship focuses on deciphering how transcription factors and associated proteins contribute to the development of neuroendocrine prostate cancer (NEPC). Using genomic, proteomic, and molecular techniques, the project will:
- Identify proteins interacting with key neuronal transcription factors like Ascl1.
- Functionally characterize shortlisted proteins to determine their role in NEPC progression.
- Explore potential therapeutic targets to revert NEPC cells to adenocarcinoma-like states.
- Integrate large-scale datasets from RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous complexes) studies.
The work will provide students with experience in high-impact cancer biology research and laboratory techniques, contributing to advanced biology jobs in academia and industry.
Key Responsibilities
- Conduct advanced genomic, proteomic, and molecular biology experiments to study neuroendocrine prostate cancer (NEPC).
- Identify and functionally characterize proteins that interact with key transcription factors such as Ascl1.
- Analyze and interpret large-scale datasets generated from techniques like RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous complexes).
- Design and perform experiments to explore how NEPC cells transition from adenocarcinoma and investigate potential therapeutic targets.
- Maintain accurate laboratory records, document findings, and ensure compliance with research protocols.
- Collaborate with the research team to contribute to publications and presentations.
Educational Qualification
Graduates or final-year undergraduates with a First/Upper Second Class degree (or equivalent) in a relevant subject (e.g., Biology, Biochemistry, Molecular Biology, Genetics).
Experience and Skills
Strong interest in molecular and cellular biology, cancer research, and laboratory techniques.
Funding & Benefits
- Full tuition fees covered for four years.
- Index-linked stipend starting at ยฃ22,500 per year.
- Access to state-of-the-art laboratories and research facilities at CRUK CI.
- Opportunity to work with an internationally recognized research team.
Application Details
- Deadline: 24th October 2025
- Course Start Date: 1st October 2026
- Apply via the University Applicant Portal: Cambridge Postgraduate Courses
- Quote reference SW47278 in your application.
- Interviews expected the week beginning 5th January 2026.