Broad Institute Biology Job Opening – Cancer Research Associate
The Broad Institute provides a vibrant research environment with close links to top academic institutions across the Boston Area and provides the potential for your contributions to be used and recognized worldwide.
One of the goals of the Broad Institute Cancer Program is to bridge the gap from annotated disease variants to biology. To achieve this goal, a multi-disciplinary team has formed to pilot cutting-edge functional genetic methodologies, create high-quality genetic reagents, develop signature-based and phenotypic assays and establish analytical methods in collaboration with the Broad community. In vitro and in vivo functional genomics, using CRISPR/Cas9 and orthogonal mutagenesis approaches represent a major component of the Team. We are scaling up efforts to deploy these tools across a panel of human cancer model systems that are capable of reading out cancer-related phenotypes. These cancer model systems are currently being used to screen cancer alleles to identify novel tumor promoters, inform genome-guided therapies and deepen our understanding of therapeutic dependencies. Our team is looking to expand these efforts and is looking for a highly motivated research associate to join the team.
Job Title: Campus Research Associate I – Cancer
- B.S./B.A. in Biology or related field required.
- RA I: 0-2 yrs of experience working in a scientific research setting a plus.
- RA II: At least 2 yrs work in a scientific research setting, preferably with functional genomics experience
- RA III: 3+ years work in a scientific research setting, with extensive functional genomics expertise, preferably with high-throughput screening experience (genetic or small molecule).
- Learn and execute the existing pipeline for the design of CRISPR genome editing tools.
Handles cell culture of human-derived cancer cell lines for high-throughput use. Uses established protocols and collaborates with Broad platforms/facilities for BL2+ and in vivo work.
- Process screening samples for downstream molecular biology.
- Works with others to refine protocols, explore novel techniques, and to incorporate them into a pipeline to establish the most relevant model systems for annotating disease variants.
- Operates and maintains laboratory equipment to complete investigations.
Prepares, orders, and maintains stocks of necessary reagents, solutions, and supplies
- Documents compile and carries out basic analyses of experimental data.
- Attends team meetings to share results, plan projects and experiments
Other tasks as requiredSKILLS AND ABILITIES:
- Strong interpersonal, communication, and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, and attention to detail are required.
- Must be an exceptional team player
- Must possess a high level of initiative and the ability to work with little supervision.
The candidate will culture human-derived cancer cell lines, design high-throughput biological assays and deploy these assays into functional genomic experiments at scale. He/She will work with wet-lab biologists, dry-lab computational biologists and the Broad Genetic Perturbation Platform to maximize the success, impact and transformative potential of these experiments. He/she will be part of a team that evaluates new technologies and approaches to create new, highly relevant in vivo cancer models.
The candidate is expected to work largely independently on a daily basis after training, but will be closely mentored by a Research Scientist and others.
Broad Institute Biology Job