PhD Studentship in Pancreatic Cancer Metastasis at Cancer Research UK Cambridge Institute – Apply Now
Are you ready to lead pioneering cancer research? The CRUK CI PhD Studentship at the Cancer Research UK Cambridge Institute invites exceptional candidates to explore how malignant cells and cancer-associated fibroblasts (CAFs) drive pancreatic cancer metastasis. With cutting-edge organoid, in vivo, and single-cell approaches, this fully funded four-year program offers an immersive route into translational oncology and therapeutic innovation.
About the Institute
The Cancer Research UK Cambridge Institute is a world-class cancer research center within the University of Cambridge. Its strengths include genomics, computational biology, imaging, and translational cancer biology. The institute fosters an inclusive, intellectually stimulating environment with access to state-of-the-art core facilities and mentorship for over 100 postgraduate researchers. Dr. Giulia Biffi’s lab focuses on tumor-stroma interactions, particularly the heterogeneity of CAFs in pancreatic cancer. Their work has shown how CAF subtypes influence tumor growth, metastasis, and treatment response.
Job Description
- PhD studentship: Dissecting malignant cell-intrinsic and -extrinsic drivers of pancreatic cancer metastasis
- Supervisor: Professor Richard Gilbertson and Dr Giulia Biffi
- Department/Location: Cancer Research UK Cambridge Institute
Project Details
Cancer-associated fibroblasts (CAFs) play a crucial role in promoting pancreatic cancer progression. This research project focuses on investigating the interactions between different CAF populations and malignant cells in pancreatic primary tumours and metastases. The ultimate goal is to develop novel therapeutic strategies to combat pancreatic cancer.
Project Highlights & Techniques
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Use organoid-derived transplantation mouse models and genetically engineered mouse lines to test CAF depletion strategies.
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Develop 3D co-culture models of tumor cells and fibroblasts
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Employ CRISPR technologies, bulk & single-cell RNA sequencing, flow cytometry, and multiplex immunofluorescence
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Perform molecular biology and biochemistry methods to validate findings
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Optionally integrate a computational component depending on the applicant’s skill set.
Funding & Stipend
This studentship includes full funding for university fees and a stipend (index-linked), starting at £22,500 per year for four years. While this covers the role, applicants are free to seek additional scholarships as needed.
Eligibility & Application
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Applicants from the UK or overseas are welcome.
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Hold or expect a First / Upper Second Class degree (or equivalent) in a relevant subject
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Prior lab experience (e.g. tissue culture, molecular biology) strongly preferred
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Willingness to work with laboratory mice throughout the PhD
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The deadline for applications is 17 October 2025, with interviews in early January 2026
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Indicate reference SW47202 in your application
How to Apply
To apply, please use the University Applicant Portal and select to commence study in October 2026.
