PhD Position at Max Planck Institute Germany
This PhD Position at the prestigious Max Planck Institute for Heart and Lung Research offers an exceptional opportunity for aspiring scientists to explore cutting-edge research in RNA/Protein Biochemistry, Molecular Biology, and Genetic Compensation. Designed as a high-impact PhD Opportunity for life science graduates, this role enables young researchers to contribute to groundbreaking discoveries in transcriptional adaptation within an internationally recognized research environment.
About the Max Planck Institute
The Max Planck Institute for Heart and Lung Research is part of the internationally respected Max Planck Society. Known for scientific excellence, the institute supports innovative research across genetics, molecular biology, and physiology. With state-of-the-art facilities and a commitment to diversity, the Max Planck Institute is a top destination for PhD Admissions and advanced life science research.
PhD Position at Max Planck Institute Details:
- Position Title: PhD in RNA/Protein Biochemistry and Molecular Biology – Genetic Compensation
- Institute: Max Planck Institute for Heart and Lung Research (W. G. Kerckhoff Institute)
- Department: Developmental Genetics (Stainier Lab)
- Location: Bad Nauheim, Germany (near Frankfurt)
- Job Type: Young Researchers / Ph.D. Position
Research Fields:
- Developmental & Evolutionary Biology
- Genetics
- Immunobiology & Infection Biology
- Physiology
PhD Position Overview
We are seeking a highly motivated Ph.D. candidate (m/f/d) to join new research projects focused on Genetic Compensation and Transcriptional Adaptation. The position is based in the Department of Developmental Genetics (Stainier Lab) at the Max Planck Institute for Heart and Lung Research.
This research addresses fundamental mechanisms underlying genetic robustness and phenotypic rescue in response to gene disruption.
Research Focus
The lab has recently identified a novel form of genetic compensation known as transcriptional adaptation. This process occurs when premature termination codons trigger mutant mRNA decay, producing decay fragments that modulate the expression of related genes.
This phenomenon has been observed in:
- Zebrafish
- Mouse
- C. elegans
- Humans
Key Open Questions Include:
- The nature and intracellular trafficking of mRNA decay fragments
- Mechanisms by which decay fragments regulate related genes
Relevant Publications:
- El-Brolosy et al., Nature (2019)
- Rossi et al., Nature (2015)
- Falcucci et al., Nature (2025)
Required Qualifications
- Master’s degree in Biology, Biochemistry, Genetics, or a related field
- Strong focus on Molecular Biology, Cell Biology, Biochemistry, and/or Genetics
- Experience or knowledge in RNA and/or protein biochemistry is an advantage
- High motivation and interest in fundamental biological research
How to Apply
Interested candidates should submit the following materials:
- Curriculum Vitae (CV)
- Short research statement (max. 2 pages) outlining research experience and interests
- Names and contact details of 2–3 references
Send applications to:
Prof. Dr. Didier Stainier
[email protected]
Additional Requirement:
Applicants must also submit an application to the International Max Planck Research School for Molecular Organ Biology (IMPRS-MOB).
