SARS-CoV-2 Virus enters the brain: Reveals new study
Study data shows that patients with COVID-19 are experiencing cognitive effects, like brain fog and fatigue.
Many researches are being performed to get insight into the reason behind it. The COVID-19 virus, like many viruses before it, affects the brain. In research reported in Nature Neuroscience, scientists noted that the spike protein could cross the blood-brain barrier (BBB) in mice.
This highly implies that the SARS-CoV-2 virus can enter the brain.
The spike protein determines which cells the virus can enter. William A. Banks, a professor of medicine, the University of Washington School of Medicine, and the lead author of the study, stated that, normally, the virus does the same thing as its binding protein. The binding proteins like spike protein normally produce damage as they withdraw from the virus and trigger inflammation by themselves. The spike protein possibly induces the brain to release cytokines and inflammatory products.
In science groups, the severe inflammation resulted from COVID-19 infection is termed as a cytokine storm. The body’s immune system, upon observing the virus and its proteins, overreacts in its effort to eliminate the invading virus. The infected individual experiences brain fog, fatigue, and other cognitive problems.
William A. Banks and his colleagues observed this effect with HIV and wished to examine if the same was occurring with coronavirus.
William A. Banks stated that the spike protein in SARS-CoV2 and the gp 120 protein in HIV-1 function in a similar way. They are glycoproteins – trademarks of proteins that bind to other receptors. Both these proteins work like the arms and hand for their viruses by getting hold of various receptors. Both cross the BBB and spike protein, like gp120, is possibly noxious to brain tissues.
He added, for one who has performed thorough work with HIV-1, gp120, and the BBB – it was like déjà vu.
His lab research on the BBB in Alzheimer’s, obesity, diabetes, as well as HIV. However, they all paused their work and started focusing on the spike protein. They joined long-time partner Prof. Jacob Raber and his teams from Oregon Health and Science University.
The research could describe several of the complexities from COVID-19.
William A. Banks stated that they understand that when you have the COVID-29 infection, you have difficulty in breathing, and that is due to the infected lungs. However, added information is that the virus invades the respiratory site of the brain and causes troubles there also.
Raber stated in their studies on the transport of spike protein was quicker in the olfactory bulb and kidney of men than women. This research might connect to the boosted susceptivity of males to more extreme COVID-19 results.
William A. Banks shares a message for people who takes this pandemic lightly:
He stated that you do not wish to mess with this virus. Much of the results that the SARS-CoV-2 virus has could be highlighted or continued and even caused by a virus entering the brain, and also those impacts could endure for a long period.