Bristol Myers job, Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMSs continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.
Job Title: Principal/Senior Principal Scientist, Cellular Phenotype
Location Seattle, Washington
Position Summary
The Cellular Phenotyping Analysis Group within Cell Therapy Analytical Development (CTAD) is responsible for the development and qualification of flow cytometry based analytical methods for release and characterization of cell therapy products. The Principle Scientist/Sr Principle Scientist will participate in the development and qualification of cell phenotyping assays support the company portfolio of preclinical and clinical-stage cell therapies, and in analytical life-cycle management of the commercial products as well. This role calls for a strong understanding of T-cell immunology, and expertise in flow cytometry to design and execute analytical assays aimed at assessing the quality, purity, and identity of the gene-edited autologous and allogeneic cells supporting the development of next generation cell therapies. The role will work closely with a multidisciplinary team of scientists and contribute to the advancement of cutting-edge cell-based therapies.
Key Responsibilities
- Develop, optimize, and qualify flow cytometry-based assays for release testing and characterization of cell therapy products.
- Perform flow cytometry experiments to develop panel design strategies and antibody cocktails for the identification, enumeration, and phenotypic characterization of target cell populations.
- Conduct in-depth data analysis and interpretation using flow cytometry software and statistical tools to interpret the experimental results.
- Collaborate with cross-functional teams to establish appropriate release specifications and quality control measures, provide SME perspectives to support process development, comparability studies, stability assessments, and product lifecycle management.
- Ensure compliance with relevant regulatory guidelines and BMS quality systems during assay development and execution.
Document experimental procedures, results, and conclusions in details in technical reports, standard operating procedures (SOPs), and contribute to the generation of regulatory submissions - Contribute to the development and implementation of innovative flow cytometry-based assays and technologies to improve the analytical capabilities of CTAD.
- Stay informed about the latest advancements and emerging trends in flow cytometry and cell therapy field, and apply new knowledge to enhance CTAD analytical strategy
- Lead initiatives related to continuous improvement of new technologies across different functions, makes strategic decisions for project teams to address the business needs.
Responsible for the direct management of a team, develop team members and lead complex programs
Qualifications & Experience
- A doctorate (PhD) in Immunology, Cell Biology, or a related field, with 5+ postdoctoral experiences.
- Extensive hands-on experience in designing and executing flow cytometry-based experiments, including panel design, sample preparation, data acquisition and analysis.
- Strong knowledge and practical experience in immunophenotyping using flow cytometry Proficiency in flow cytometry data analysis software (e.g. FlowJo, FCS Express) and statistical analysis tools
- Demonstrated skills working collaboratively with cross-functional teams, maintaining strong stakeholder relationships, influencing direction, voicing an opinion, and communicating effectively
- Excellent problem-solving skills and the ability to troubleshoot technical issues independently
Strong communication skills, with the ability to present scientific data and findings to multidisciplinary teams and stakeholders. - Ability to work effectively in a fast-paces and collaborative environment, with a focus on achieving goals in a timely manner.
Familiarity with gene editing technologies (e.g. CRISPR/Cas9) and cell engineering approaches. - Understanding of regulatory guidelines and quality systems related to cell therapy development, manufacturing, and analytical control strategies.
Previous managerial experiences in goal-setting, performance evaluations and coaching. - The starting compensation for this job is a range from $114,000-$163,000 plus incentive cash and stock opportunities (based on eligibility).
Bristol Myers Squibb Cell, Bristol Myers, Bristol Myers
