Novartis Gene Therapy Scientist Vacancy – Molecular Biology

Novartis Gene Therapy Scientist Vacancy – Molecular Biology

The Scientist II, Analytical Sciences – Gene Therapy Early Pipeline, supports early-stage recombinant adenovirus-associated virus (rAAV) gene therapy pipeline portfolio. Check out all the details on the same below:

This is the reality of parents whose children have Spinal Muscular Atrophy (SMA) and it’s the reason why we at Novartis Gene Therapies are laser-focused on bringing hope and possibility to those devastated by rare genetic diseases.

Job Title: Scientist II, Analytical Sciences – Gene Therapy Early Pipeline

Job Location US-CA-San Diego

Job ID 2021-6153

Qualifications

  • Bachelor’s in Analytical Chemistry, Molecular Biology, Cell Biology, Biochemistry, Virology, or a related field with 6 years relevant experience or Masters with 4 years relevant experience or Ph.D. with 2 years relevant experience.
  • Strong hands-on experiences on analytical techniques such as RT-PCR, qPCR, ddPCR, Immunoassays such as ELISA, SDS-PAGE, and Western blot.
  • Extensive experience in analytical chemistry and molecular biology.
  • Passionate about new analytical technologies/methods to assess the quality of research vectors, including characterization and release assays for early pipeline development projects.
  • Familiarity with standard analytical techniques for characterizing rAAV Vectors (SEC, AUC, Purity, CE, RP-HPLC, DLS, LC-MS, etc).
    Highly organized, attentive to detail, and able to work under tight timelines in a collaborative team setting.
  • Excellent interpersonal and communication skills.
  • Hands-on experiences on a variety of biochemical and biophysical assays including HPLC (SEC, IEC, RP), osmolality, Analytical ultra-centrifugation (AUC), Light Scattering (SLS, DLS & MALS), capillary electrophoresis sodium dodecyl sulfate (CE-SDS), and UV-Vis Spectrometry.
  • Ability to troubleshoot and think analytically, multitask and support multiple projects simultaneously.
  • Quick learner, highly motivated, hard-working, and detail-oriented.

The level of this position will be based on the final candidate’s qualifications

Responsibilities

  • Develops and optimizes methods for extraction of DNA, RNA, and proteins followed by testing using various molecular biology techniques such as qPCR, PCR, qRT-PCR, Immunofluorescence, Western blotting, and ELISA to support characterization of novel AAV gene therapy vectors and cell line development.
  • Develops and executes ddPCR and ELISA assays for genomic titer, capsid titer, and other testing are required to enable the progression of early pipeline development projects in a timely fashion.
  • Supports or contributes to the development or optimization of new analytical methods for the characterization of gene therapy drug products and drug substances.
  • Develops vector lot release testing strategy and reviews all testing documents and data in preparation of vector release (COA) as part of the early pipeline project deliverables.
    Performs a wide variety of laboratory tasks and experiments.
  • Maintains electronic laboratory notebook that records all aspects of experimental design and results, following good documentation practices.
  • Critical thinking, excellent data analysis using software such as Microsoft Excel, JMP, Prism, R scripts, and other software as needed with minimal supervision and interpretation skills.

Novartis Gene Therapy Scientist

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